Opera Medica et Physiologica

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Full-length research paper
Printed July 16, 2020;
Published ahead of print July 12, 2020; Printed July 16, 2020; OM&P 2020 Volume 7 Issue 2, pages 12-23; doi:10.24411/2500-2295-2020-00002
Abstract Full Text

The features of ischemic brain injury outcome in C57BL/6 mice depending on the right or left common carotid artery occlusion are characterized. The right-hemispheric focal ischemia decreases the body weight, causes spatial memory impairment, and activates the development of a pronounced long-term neurological deficit characterized by ipsilateral limb paralysis, ptosis and muscle dystrophy, which is accompanied by perivascular brain tissue edema. In the left-hemispheric focal ischemia, the neurological status impairments are also observed, but they less pronounced than in case of right-hemispheric ischemia. Moreover, preference to study novelty is reduced, and long-term emotional strain is revealed. The peculiarity of ischemic injury using the left common carotid artery occlusion is accompanied by the presence of hemorrhages and dilated capillaries in the damaged brain hemisphere.


Full-length research paper
Printed July 16, 2020;
Published ahead of print July 12, 2020; Printed July 16, 2020; OM&P 2020 Volume 7 Issue 2, pages 24-29; doi:10.24411/2500-2295-2020-00003
Abstract Full Text

The present study is dedicated to the investigation of slow-waves in heart rate activity of healthy persons. Approaches to the description of the cardiovascular functional states using the dynamic characteristics of the amplitudephase coupling mechanisms of the electrocardiographic signal are described. Amplitude-phase coupling based pattern extracting was carried out. Suggested informative features and patterns of regulatory systems will allow the analysis of the diagnostic procedure results with reference to the central mechanisms of regulation and control.


Full-length research paper
Printed July 16, 2020;
Published ahead of print July 12, 2020; Printed July 16, 2020; OM&P 2020 Volume 7 Issue 2, pages 30-53; doi:10.24411/2500-2295-2020-00004
Abstract Full Text

The aim of this study was to examine the antidepressant-like responses to vitamin D3 (VD3) subcutaneous (s.c.) supplementation (1.0, 2.5, and 5.0 mg/kg) in middle-aged long-term ovariectomized (OVX) rats treated with a low dose of 17β-estradiol (17β-E2) (0.5 μg/rat, s.c.) exposed to the chronic unpredictable mild stress (CUMS). Sucrose preference (SPT), forced swimming (FST), and open-field (OFT) tests were performed to measure anhedonia, depressionlike state, and locomotor/grooming activities, respectively. Glial cell line-derived factor (GDNF) levels in the hippocampus of middle-aged long-term OVX rats following CUMS treated with VD3 were measured using ELISA and Western blotting. The serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the hippocampus were detected by high performance liquid chromatography (HPLC). The findings demonstrated that VD3 (1.0 mg/kg, s.c.) in a combination with a low dose of 17β-E2 increased sucrose consumption in the SPT and decreased depression-like behavior in the FST of middle-aged long-term OVX rats exposed to CUMS. This dose of VD3 elevated hippocampal GDNF protein expression and increased 5-HT/5-HIAA levels in middle-aged long-term OVX rats plus 17β-E2 compared to the middle-aged OVX rats plus 17β-E2 with CUMS. The other two doses of VD3 (2.5 and 5.0 mg/kg, s.c.) failed to modify both GDNF protein levels and 5-HT turnover in the hippocampus of middle-aged long-term OVX rats treated with 17β-E2 exposed to CUMS. Thus, treatment with a low dose of VD3 (1.0 mg/kg, s.c.) in a combination with a low dose of 17β-E2 enhanced antianhedonic-/antidepressant-like effects of both substances in middle-aged long-term OVX rats exposed to CUMS.


Full-length research paper
Printed March 27, 2020;
Published ahead of print March 20, 2020; Printed March 27, 2020; OM&P 2020 Volume 6 Issue 1, pages 14-19; doi:10.20388/omp2020.001.0067
Abstract Full Text

In this paper we studied the RBC electrophoretic mobility, cytomorphological and cytogenetic parameters of buccal epithelial cells and morphology of adrenal glands under the influence of adrenalin which was injected to simulate a stress in rat body. It’s established that an initial increase of the activity of brain substance neuroendocrinocytes (during the first hour) with further increase of the activity of the adrenal cortex (from 1 day) are combined with the change of RBC electrophoretic mobility index: at first it decreases and then it increases. Besides the cells with signs of cytotoxic changes appear. The absence of cells with karyopyknosis in stressed animal bodies indicates that the mechanisms of natural resistance of buccal epithelial cells preserve. It’s associated with the development of adaptive processes.


Full-length research paper
Printed March 27, 2020;
Published ahead of print March 20, 2020; Printed March 27, 2020; OM&P 2020 Volume 6 Issue 1, pages 5-13; doi:10.20388/omp2020.001.0066
Abstract Full Text

The article presents a brief history of the formation of scientific ideas about kidney physiology and the mechanisms of water-salt metabolism regulation in Novosibirsk, as well as the role of some physiologists in the development of these views. The beginning of the development of renal physiology in Novosibirsk was the idea by A.G. Ginetsinsky about the reflex osmoregulatory system of the organism, that was developed by his students (L.K. Velikanova, Ya.D. Finkinstein, L.N. Ivanova, Yu.V. Natochin, L.I. Kurduban). Later on, the veiws about the ion-regulating mechanisms and age-specific features of their formation in the ontogenesis of humans and animals have been formed (A.Ya. Terner, R.I. Aizman, I.V. Pantyukhin). The role of interconnections in this direction between the researchers from Novosibirsk and scientists from the USA (L. Rabinowitz), Sweden (A. Aperia, G. Celsi), Israel (H. Garty, S. Karlish) and others were shown. Knowledge of the history of the development of renal physiology in different countries and the results of cooperation between researchers play an important role in understanding the development prospects of this scientific area.


Printed May 31, 2019;
Published ahead of print May 20, 2019; Printed May 31, 2019; OM&P 2019 Volume 5 Supplement S 1, pages 7-11
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Function and plasticity of synapses.pdf475.73 KB

Printed May 31, 2019;
Published ahead of print May 20, 2019; Printed May 31, 2019; OM&P 2019 Volume 5 Supplement S 1, pages 12-16
Abstract Full Text

Printed May 31, 2019;
Published ahead of print May 20, 2019; Printed May 31, 2019; OM&P 2019 Volume 5 Supplement S 1, pages 17-23
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Neuron-glia interactions.pdf500.76 KB

Printed May 31, 2019;
Published ahead of print May 20, 2019; Printed May 31, 2019; OM&P 2019 Volume 5 Supplement S 1
Abstract Full Text
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author index.pdf284.76 KB

Printed May 31, 2019;
Published ahead of print May 20, 2019; Printed May 31, 2019; OM&P 2019 Volume 5 Supplement S 1, pages 1-6
Abstract Full Text

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