Opera Medica et Physiologica

Morphological Disturbances of Brain Structures in Traumatic Brain Injury and Their Correction with Use of Cytoprotectors

Published ahead of print December 15, 2020; Printed December 17, 2020; OM&P 2020 Volume 7 Issue 4, pages 5-12; doi:10.24411/2500-2295-2020-10009

An experimental trauma was performed for the studying of morphological changes characteristics of the brain under the action of neuroprotectors soon after the brain injury. The closed craniocerebral injury was modeled by the free fall of a load on the parietooccipital area of the brain. We made repeat studies of the influence of succinate medicaments (cytoflavin and mexicor) on histological examination and morphometric analysis of the microcirculatory bed of the cerebral cortex. The experiments were made on the 1st, 3rd, 7th, and 12th day after the traumatic brain injury. An experimental morphological study has established that the use of neuroprotetors after the trauma recovers of brain tissue and positively affects the angio- and cytoarchitectonics of the cerebral cortex in the posttraumatic period.