Comparative Evaluation of the Effect of Low-Intensity Electromagnetic Noise Signals in the Microwave Range on the Induction of Metabolic and Vascular Adaptation Reactions in Experimental Thermal Burns

Currently, we continue to actively develop a high-tech rehabilitation method of microwave therapy using sub- and millimeter-wave radiation sources. However, the question of the feasibility of its use in the rehabilitation of patients with burn injuries is not sufficiently studied. In this connection, the works analyzing the effectiveness of the influence of different micro-wave ranges on the nature and degree of development of adaptive metabolic and vascular reactions in the early period of trauma, which affect the outcome of the burn, become particularly relevant. The study was carried out on male rats of the Wistar line under conditions of experimental contact thermal burn of the IIIА degree on an area of 20% of the dorsal surface of the body. A 7-day course of point non-contact exposure to broadband microwave emitters of various ranges with a radiation power of 10 µW on the occipital protuberance area was started after the rats were released from anesthesia when the contact burn was applied. The vascular status, the state of oxidative stress and energy homeostasis were assessed by the intensity of oxidative processes, antioxidant protection, and the total microcirculation index with a wavelet analysis. The obtained data reliably revealed a more pronounced favorable effect on the level of adaptive reactions in the range of 150,179-150.664 GHz, which contains the frequencies of radiation and absorption of nitric oxide. This should be taken into account when choosing frequency-energy parameters and developing a potential method of rehabilitation in the acute period of burn injury.