Opera Medica et Physiologica

ENU Mutagenesis as a Tool for Identifying Novel Mouse Models of Epilepsy

Published ahead of print March 14, 2021; Printed March 15, 2021; OM&P 2021 Volume 8 Issue 1, pages 5-11; doi:10.24412/2500-2295-2021-1-5-11

Epilepsy affects around 1% of the population in the world. Thus, it is imperative that new more effective and safe treatments be found. In order to understand the nature of epilepsy, new and better animal models are needed in that they offer valuable resources for researchers. Such models provide an opportunity to characterize seizures in the whole organism, to understand the molecular basis of these processes and to test the effectiveness of treatments and therapies. In this study, we have shown that screening after chemical mutagenesis can be used as a tool to identify new genes that may be involved in the mechanism of epilepsy formation.