The energy shortage, as well as the lack of antioxidant micronutrients that occur with severe thermal lesions, lead to poor clinical outcomes. It is important to carry out timely and effective therapy that helps maintain the redox and energy balance of the burned body. The aim of this work was to evaluate the energy status of red blood cells in severely burned patients with the use of antioxidant therapy and hyperbaric oxygenation on different days of therapy. The study involved 60 practically healthy people (norm) and patients with burns of I-II-III degree with different localization over 25% of the body surface. The age of patients is from 20 to 87 years. The data obtained suggested the effectiveness of the use of antioxidant therapy in burn patients due to the activation of oxidoreductases that support energy metabolism. The combined use of HBO and antioxidant nutrients in addition to standard therapy presumably contributed to maintaining the energy and redox balance of the body in patients with burns.