Histopathological Scoring System and Physiological Changes in Women With Spontaneous Miscarriage

This study aims to investigate the histopathological changes in the placental tissue of women who have experienced spontaneous miscarriage using a scoring system, as well as the physiological changes in the serum of these women. The focus is on those who do not have any chronic diseases, thyroid issues, blood clotting disorders, or blood group incompatibility. Samples are analyzed for TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus). Samples that test positive for these infections are excluded from the study. Additionally, cases of ectopic pregnancy, septic abortion, and blighted ovum abortion are also excluded. Materials and methods: The study involved 30 patients who experienced spontaneous miscarriages. These participants were divided into two groups according to the duration of their pregnancies. Placental tissue samples from those women were processed, stained, and examined for histopathological changes. Moreover, physiological exams were performed to measure levels of prolactin and estrogen in these women as well. Results: The study identified significant differences in histopathological changes (intervillous fibrinoid deposition, perivillous fibrinoid deposition, inflammatory infiltrate, hemorrhage, increased angiogenesis, and hydropic change) in placenta tissue between groups G1 and G2, with more prevalent changes observed in G1. On the other hand, there is no significant difference between prolactin and estrogen hormones in G1 and G2. Conclusion: There was a relationship between increased histopathological changes in very early spontaneous miscarriages and the increase in maternal age. While there is no difference in prolactin and estrogen levels.