High Expression of Long Non-Coding RNA H19, UCA1 Is Associated With Muscle Invasive Bladder Cancer

Bladder cancer is one of the most common cancers worldwide. Recently, much attention has been focused on the study of long non-coding RNAs (lncRNAs) that are a class of noncoding RNA transcripts with length over 200 nucleotides localized in the nucleus and thought to play a regulatory role in carcinogenesis. In our study the expression levels of lncRNAs H19 and UCA1 were screened in normal and tumor bladder tissue of the patients with muscle invasive bladder cancer. The expression level of lncRNAs in tumor samples compared with normal tissue was increased by approximately 4 times: for H19 fold change (FC) = 4.03 (p-value = 0.0003), and for UCA1 FC = 4.83, (p-value = 0.0165). We performed a ROC-analysis for a combination of these lncRNAs, and the AUC was 0.747, model accuracy is 73.3%.