Aging is a natural and inevitable process that worsens the quality of life and shortens its duration. In the process of aging, the cardiovascular system undergoes significant restructuring, diastolic dysfunction is observed, vascular stiffness increases and vasodilation decreases. α2-ARs are widely distributed in the body and are involved in the regulation of heart and vascular functions. In pathological conditions, there is an increase in the expression of α2-AR subtypes, a violation of their functions, and a decrease in the effectiveness of the associated signalling cascades. The study aimed to investigate the effect of the α2-AR agonist clonidine hydrochloride at concentrations of 10-9-10-6 M on the inotropy, chronotropy and coronary flow of the old rats isolated heart. α2-AR stimulation changes all the studied parameters of the old rats isolated heart. The force of left the ventricular myocardium contraction decreases at concentrations of 10-9 and 10-8 M, and increases at concentrations of 10-7 and 10-6 M. The α2-AR agonist causes a decrease in heart rate in all studied concentrations. Stimulation of α2-AR in lower concentrations (10-9 - 10-7 M) reduces coronary flow, and the maximum concentration of clonidine hydrochloride (10-6 M) increases.
Opera Medica et Physiologica
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