Abstract:
Chronic kidney disease biomarkers are not studied well yet. Klotho and fibroblast growth factor 23 can be used as sensitive chronic kidney disease biomarkers, as well as single nucleotide polymorphisms of renin-angiotensin-aldosterone system genes may signal the risk of a genetic predisposition to this pathology. In this regard, the purpose of our work is to study the association of polymorphisms of renin-angiotensin-aldosterone system genes with physiological indicators of end-stage renal disease. Levels of fibroblast growth factor 23, Klotho, urea, creatinine, albumin, C-reactive protein, complete blood count parameters were considered in end-stage renal disease patients and control group. Also single nucleotide polymorphisms of AGT (rs4762), AGTR1 (rs5186) and AGTR2 (rs1403543) genes were determined. As a result, a statistically significant increase of fibroblast growth factor 23, urea and creatinine in the plasma of patients with end-stage renal disease was revealed. Statistically significant relationships were found between the complete blood count parameters, between albumin level and parathyroid hormone, between mean corpuscular hemoglobin and C-reactive protein. No difference of the frequency of polymorphisms of the studied genes between the groups was found. An increase of albumin and decrease of Klotho levels were recorded in carriers of the heterozygous genotype of the rs5186 polymorphism and in the case of a complete replacement for the wild allele in the FGFR2 gene (rs1403543) in the group of patients with end-stage renal disease. In the control group a relationship was found between the levels of urea, albumin and creatinine and the carriage of rs4762 and rs1403543 polymorphisms.
