Study of the Distribution of Frequencies of Alleles and Genotypes of Polymorphic Variants rs1800795 of the IL6 Gene, rs1800629 of the TNFA Gene and rs10490770 of the LZTFL1 Gene Associated with COVID-19 in Populations of the Volga-Ural Region

The study of the severity and consequences of infectious diseases is a relevant subject of research throughout the world, which was directly demonstrated by the situation with the 2020-2023 coronavirus pandemic. In our study, we analyzed a distribution of genotypes and alleles frequency of polymorphic variants of the IL6 rs1800795, TNFA rs1800629 and LZTFL1 rs10490770 gene polymorphisms, which were previously linked to the pathogenesis of COVID-19, in populations of Burzyan Bashkirs, Sterlibashevsky Bashkirs, Permsky Bashkirs, Kazan Tatars, Chuvash, Udmurts, Mari, Komi and Mordvins. Statistically significant differences were identified in the IL6 rs1800795 between the populations of the Burzyan Bashkirs and the Mari and Komi (p < 0.05). The Sterlibashevsky Bashkirs, Permsky Bashkirs and Udmurts also statistically significantly differed from the Komi population (p < 0.05). When studying the TNFA rs1800629, statistically significant differences were identified between the populations of Sterlibashevsky and Permsky Bashkirs and the Udmurts population (p < 0.05). Analysis of the LZTFL1 rs10490770 revealed statistically significant differences only between the Udmurt and Mari populations (p < 0.05). The data indicate that despite the geographic proximity of the examined populations of the Volga-Ural region, they were able to preserve the uniqueness of their gene pool.