Assessment of the Harmful Effect of Duprost drug on testes of Albino Mice

This study was designed to assess the harmful impact of Duprost on the testes of experimental animals. The animals were divided into 3 categories: control, acute, and chronic; the last two were further divided into subgroups. All acute subgroups were given a lonely oral dosage of 0.5, 0.12, 0.08, and 0.04 mg/kg for 24 hours. The chronic subgroups were given a daily dosage of 0.12, 0.08, 0.04 mg/kg for 42 days. The sections of treated testes of acute and chronic sets showed pathological alterations mainly in dosages (0.12 mg/kg and 0.08 mg/kg). The higher dosages cause cellular depletion, necrosis and lysis of the testicular interstitium, hyperplasia and increased thickness of the interstitium. Moreover, there was marked hypertrophy, marked tubular dilation and deterioration with severe degeneration and necrosis of lining epithelium with a loss of stereocilia in epididymis tissue.