A major problem of medicine is the prevention, treatment and rehabilitation of patients with congenital malformations of the maxillofacial region. This is due to their frequency, the severity of anatomical and functional disorders, as well as the complexity of social adaptation of patients. Cleft lip and palate are highly common malformations with a significant variation of risk factors. The updating of epidemiological data in certain regions of Russia makes it possible to identify the dominant causal mechanisms of the occurrence of defects, to determine the necessary directions for improving preventive and diagnostic measures, treatment and tactics of dispensary supervision of patients. The analysis of the incidence of congenital malformations of the maxillofacial region in the city of Nizhny Novgorod and the Nizhny Novgorod region of Russia over the past 19 years has been carried out. The risk factors for the development of anomalies, the structure of morbidity, the type and nature of the therapeutic measures carried out were determined.