Changes in the General Condition and Blood Indicators of Mice in the Long Period After Irradiation of Chest

A study was made of the general condition, changes in the relative mass of internal organs and blood parameters of C57Bl/6 mice 3 months after local irradiation of the chest. Irradiation was carried out in five equal fractions with total doses of 5, 10 and 20 Gy. Single cases of death of irradiated animals were noted in each group 2 months after irradiation. 90 days after irradiation, an increase in the relative mass of the lung was noted in all groups of irradiated animals, as well as a decrease in the relative mass of the spleen and liver. A decrease in the number of platelets in all groups after irradiation was established, as well as a change in erythrocyte indices, which was most pronounced in groups irradiated at doses of 10 and 20 Gy. An increase in the activity of transaminase enzymes in the blood serum of animals depending on the dose of irradiation, an increase in the activity of LDH and phosphatases, as well as a decrease in the level of total protein were noted, which indicates damage to the organs of the thoracic region and liver and persistent metabolic disorders in animals 90days after local irradiation.