Correlation Between Bone Mineral Density Biomarkers and Disease Progression in Hyperparathyroidism

Hyperparathyroidism (HPT) is a complex endocrine condition true cppHip1 which is characterized by calcium imbalance with abnormal bone turnover with significant skeletal morbidities. The aim of the study was to investigate links between BMD markers and clinical evolution of variants of hyperparathyroidism, mainly focusing on primary and secondary forms related to vitamin D deficit and chronic renal failure. An observational cross-sectional study for 11 months on 200 adult male patients was conducted and the patients were divided into four groups as healthy control group, primary hyperparathyroidism (PHPT), secondary hyperparathyroidism (SHPT) due to vitamin D deficiency and SHPT due to renal failure. Plasma biochemical, hormonal and bone metabolic markers from blood samples were measured as previously described. The two groups presented different metabolic profile, including higher PTH levels, alterations in calcium and vitamin D homeostasis and markers for high bone turnover. This was particularly the case for kidney-related SHPT. PTH was inversely related to calcium and vitamin D3 and directly related to the bone resorption markers suggesting different patterns of skeletal remodeling. Conclusions: These findings highlight the progressive skeletal consequences of hyperparathyroidism and point to a potential use for these biochemical stand-ins in determining severity. Severe bone disease may be avoided with early detection and treatment of metabolic abnormalities.