Study on the Effect of Clobetasol on Protein Composition and Neurotrophic Factor Levels in Somatic Nerve Injury

Previous studies have demonstrated that administration of clobetasol at a concentration of 0.25 mg/kg stimulates the synthesis of neurotrophic growth factors, likely triggering the phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways, resulting in increased levels of structural and axonal proteins necessary for the functional recovery of damaged somatic nerves. However, it has been shown that using higher concentrations of the drug (0.5 and 1.0 mg/kg) leads to a reduction in both structural and axonal proteins in both segments of the nerve conduit and exerts an inhibitory effect on the expression of neurotrophic factors responsible for cytoskeletal remodeling and axonal growth regulation.