The safety of titanium dioxide nano-particles (TiO2NPs) is currently being questioned. TiO2NPs have multiple uses in disinfectants, plastics, cosmetics, and food coloring. Our goal was to determine if administering Baicalin (50 mg/kg body weight) could help lessen the harmful effects caused by TiO2NPs (100 mg/kg body weight) in rats. By reducing kidney damage from TiO2NPs, treatment with Bai led to lower levels of creatinine (Cr), urea (Ur), and uric acid (UA). The harmful effects of TiO2NPs can be counteracted by Baicalin, which has demonstrated its ability to protect the kidneys. Additionally, it can restore balance between oxidation and antioxidants by increasing CAT, SOD, GSH, and reducing malondialdehyde levels. Not only does it exhibit anti-inflammatory effects by downregulating IL-6 and TNF- and increasing IL-10, but it also contributes to maintaining equilibrium in the body.
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 03_Abdulhadi_23-33.pdf | 1.28 MB |
