Opera Medica et Physiologica

Methoxamine Plays a Role in the Regulation of the Electrical Activity of Newborn Rats

Published ahead of print June 04, 2023; Printed June 05, 2023; OM&P 2023 Volume 10 Issue 2, pages 59-64; doi:10.24412/2500-2295-2023-2-59-64

Various studies have led to our present knowledge of α1-adrenoreceptors and their role in the regulation of cardiovascular physiology. Our study aimed to study the effect of the α1-adrenergic receptor agonist methoxamine on the frequency of spontaneous activity and electrical activity parameters of the atrial myocardium with a preserved sinus node and an imposed rhythm in newborn rats. In working cardiomyocytes of newborn rats with a preserved sinus node, methoxamine caused an increase in the frequency of spontaneous activity. α1-adrenergic receptor agonist methoxamine increased the duration of the repolarization phase of the action potential in both the imposed and the own rhythm.