Phenols are used to make detergents, some prescription drugs, pesticides, and other industrially manufactured products. Consuming a range of phenolic compounds found in food reduces the risk of health issues because they act as antioxidants. Paclitaxel is a commonly used treatment for a variety of malignancies. It has been shown that higher doses of paclitaxel are more successful in treating a variety of cancer types. Nevertheless, in addition to inhibiting the growth of cancerous cells, chemotherapy medications have some unfavorable side effects. Twenty-four albino male rats were divided into three groups, and each group consisted of eight rats. Group I: negative control, injected with normal saline. Group II: positive control, received paclitaxel for 4 doses at 7 mg/kg over 30 days without phenol treatment. Group III: rats were treated with crude phenol extract at 10 mg/kg administered orally, along with paclitaxel, and samples were collected after 30 days. The results showed that the crude phenol extract reduced creatinine, urea, uric acid, AST, ALT, and ALP activity, while it increased SOD levels. The rats treated with crude phenol extract showed improvement in liver and kidney histopathological alterations. In conclusion, we investigated the possible advantages of crude phenol extract from Cinnamomum cassia L. in reducing the side effects of paclitaxel, a chemotherapy drug.
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