Objective: To investigate the levels of exhaled nitric oxide (FeNO) in children with mild bronchial asthma (BA) depending on disease control and the dynamics of FeNO levels after a 3-month course of treatment with leukotriene receptor antagonists (LTRA) or low doses of inhaled glucocorticosteroids (ICS). Materials and Methods: One hundred twenty children aged 5-15 years were examined, including 90 children with mild BA and 30 healthy controls. Measurements included FeNO, concentrations of nitrite (NO2-), nitrate (NO3-), their total concentration (TNN), and 3-nitrotyrosine in exhaled breath condensate. The main group was randomized into two subgroups: subgroup A - 60 children receiving montelukast, and subgroup B - 30 children receiving ICS. Results: In children with partially controlled BA, levels of FeNO, TNN, and NO3- in exhaled breath condensate were significantly higher compared to those with fully controlled BA. Following treatment with LTRA and ICS, a significant reduction in FeNO, TNN, and NO3- was observed in both subgroups. Conclusion: Dysregulation in the nitric oxide system plays a significant role in the pathogenesis of BA in children. Measurement of nitric oxide cycle parameters may be utilized for monitoring the effectiveness of basic therapy.
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