The Experience of Studying the Chronic Effects of Ethanol Consumption and Withdrawal in Danio rerio Fish: From Behaviour to Neurochemistry and Back

In recent years, Danio rerio fish (D. rerio) have become increasingly used in the field of biological narcology to study the effects of narcogens on behavior and neurochemistry in the brain. In order to study the effect of ethanol, D. rerio was used most often. We analyzed all available studies and summarized information on behavior and neurochemistry obtained using different protocols for modeling chronic ethanol exposure and withdrawal status on D. rerio. The analysis of the publications allowed us to identify three approaches used to model chronic alcoholism on D. rerio. Such a generalization of the available data will be beneficial for researchers who use D. rerio as a model object to solve their problems in this area of research.