A comparative analysis of the effects of serotonin (200 μg/kg), dopamine (60 μg/kg), promethazine (2 mg/kg) and sulpiride (1 mg/kg) administered once intraperitoneally on heart rate variability in male non-linear rats was carried out. Serotonin and dopamine do not change heart rate, but increase the centralization index by 122% (p < 0.05), serotonin due to an increase in the power of LF waves by 136% (p < 0.05), dopamine due to a downward trend power of HF waves by 51% (p < 0.1) compared to the control. Promethazine reduces the power of LF and VLF waves by 64-66% (p < 0.05) and the index of centralization (p < 0.01), while the proportion of HF waves in the spectrum increases to 75%, which is higher than the control (p < 0.01). Sulpiride increases heart rate frequency by 25% (p < 0.01) and the index of centralization (p < 0.001), reduces the power of HF-waves by 70 % (p < 0.001) from the initial state, increases the power of LF-of waves by 336% and VLF-waves by 197% (p < 0.001), so the total proportion of LF and VLF waves increases to 85%, which is higher than the control (p < 0.05). The results suggest that peripheral serotoninergic and dopaminergic mechanisms have opposite effects on heart rate variability.
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