The effect of gas-discharge plasma radiation on the biochemical parameters of blood and urine of intact animals and animals with acute alcohol intoxication was investigated. Measurements of the content of medium-mass molecules (MMM), creatinine, urea, glucose, lactate and hemoglobin in the blood and 14 physicochemical indicators of the urine test were carried out. Acute alcohol intoxication (AAI) was simulated by intraperitoneal injection of 33% ethanol at a dose of LD50. The treatment was carried out by an experimental pulsed (10 Hz) device generating radiation of spark discharge plasma. It was revealed that exposure to plasma radiation does not lead to changes in the biochemical parameters of blood and urine of intact animals. In the model of AAI, the development of protein-creatininia, urobilinogenuria, and an increase in the specific gravity of rat’s urine was observed. The total level of MMM and hemoglobin in the blood increased, lactic acidosis developed. After exposure to plasma radiation in animals with AAI, blood and urine parameters normalized, which is probably associated with the activation of the organism's adaptive and antioxidant reserves. Thus, the positive effect of spark discharge plasma radiation on the organism during acute ethanol intoxication has been shown.
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