Opera Medica et Physiologica

A Single Episode of Seizures Induced by Pentylenetetrazole is Followed by a Cognitive Decline

Author Affiliations

V.A. Aniol , A.Yu. Ivanova-Dyatlova , A.O. Tishkina , V.V. Fominykh , A. Kvichanskii , N.V. Gulyaeva  

Institute of Higher Nervous Activity and Neurophysiology, RAS, Moscow, Russia

Corresponding author: 

V.A. Aniol (aniviktor@narod.ru)


Single episode of generalized tonic-clonic seizures induced by pentylenetetrazole led to slowly developing memory impairments in rats, accompanied by elimination of excessive newly generated young cells which were born in the hippocampus soon after the seizures and transient activation of microglial cells in this neurogenic niche.