Molecular-Genetic Characteristics of M. Hominis Clinical Isolates Efflux Systems

The widespread occurrence of drug-resistant urogenital mycoplasmas and the high rate of their genetic variability make it possible to consider Mycoplasma hominis as a natural reservoir of antibiotic resistance determinants. Multiple drug resistance of many bacterial types is due to the active elimination of the antibiotic from the cell through various efflux systems. The genome structure of ten clinical isolates Mycoplasma hominis was studied using next-generation sequencing. The molecular genetic characterization family MATE proteins of Russian isolates M. hominis genes using bioinformatics analysis was obtained in the first. It has been established that proteins of the transport systems (ABC-transporters) and MATE play an important role in the formation of antibiotic resistance in urogenital mycoplasmas. The activity and functioning of transport systems are associated with the presence of mutations in the genes encoding regulatory proteins. Efflux systems should be considered as promising potential targets in the creation of new generation antibacterial drugs.