Opera Medica et Physiologica


A Single Episode of Seizures Induced by Pentylenetetrazole is Followed by a Cognitive Decline


According to different studies, between 5% and 10% of people suffer a single isolated seizure at some time in their life. However, little is known about effects of a single seizure on the cognitive function, and clinical investigations of this issue are not easy to perform. The aim of our study was to follow the time course of delayed effects of generalized clonic-tonic convulsions on learning and memory functions in rats.


PDF icon 10.20388omp2015.00s1.0015.pdf510.03 KB


Single episode of generalized tonic-clonic seizures induced by pentylenetetrazole led to slowly developing memory impairments in rats, accompanied by elimination of excessive newly generated young cells which were born in the hippocampus soon after the seizures and transient activation of microglial cells in this neurogenic niche.

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