Opera Medica et Physiologica

Huntington disease

Pathobiology of Neurodegeneration: The Role for Astroglia

The cellular basis for neurological diseases: the central role for neuroglia.

PDF icon OMP_2016_01_0019.pdf584.08 KB


The common denominator of neurodegenerative diseases, which mainly affect humans, is the progressive death of neural cells resulting in neurological and cognitive deficits. Astroglial cells are central elements of the homoeostasis, defence and regeneration of the central nervous system, and their malfunction or reactivity contribute to the pathophysiology of neurodegenerative diseases. Pathological remodelling of astroglia in neurodegenerative context is multifaceted. Both astroglial atrophy with a loss of function and astroglial reactivity have been identified in virtually all forms of neurodegenerative disorders. Astroglia may represent a novel target for therapeutic strategies aimed at preventing and possibly curing neurodegenerative diseases.

Subscribe to RSS - Huntington disease