Opera Medica et Physiologica

Effect of Chronic Exogenous Stimulation of Neurotrophic Factor BDNF on Mitochondria-Endoplasmatic Reticulum Contacts in Immature Neurons

Published ahead of print September 20, 2021; Printed September 28, 2021; OM&P 2021 Volume 8 Issue 3, pages 65-71; doi:10.24412/2500-2295-2021-3-65-71

Mitochondria-endoplasmic reticulum contacts (MERC) are known as one of the key regulators of many cell functions. In particular, MERC effects on the mobility and morphology of mitochondria, exchange of calcium and lipids between organelles, and participates in the processes of autophagy and apoptosis that are crucial for neuronal development. MERC can influence the functioning of the neurotrophic factor BDNF through the activation of the Sigma-1 receptor. That points to the presence of feedback i.e. itself BDNF influence on the structural characteristics of MERC. At the same time, the effect of chronic stimulation of BDNF or blockade of TrkB receptors on an ability to form contacts between mitochondria and ER is different and depends on cellular compartment.