Opera Medica et Physiologica

M. Druzin

Regulation of Neuronal Chloride Homeostasis: a new Role for Extracellular Matrix

Neuronal signaling relies on ion fluxes through membrane-bound channels. Such fluxes are allowed due to the transmembrane ionic gradients created and maintained by membrane transporters. The neuronal gradient for chloride, an anion mediating most of the inhibition in the mature CNS, is the result of activity of two chloride transporters working in opposite directions, NKCC1 moving chloride in and KCC2 moving chloride out of the cell.

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