Submitted by Root Addmin on Mon, 2017-12-18 18:03
The substantia nigra is the midbrain area consisting of two parts: the pars compacta and the pars reticulata. The neurons of the pars compacta are mostly dopaminergic with a small portion of glutamatergic cells, whereas those of the pars reticulata are predominantly GABAergic (Nair-Roberts et al., 2008). The dopaminergic nigral neurons are most prone to degeneration in Parkinson’s disease and very vulnerable to various neurotoxins.