Opera Medica et Physiologica

A.D. Perenkov

Correlation between Muc1, Il-32 Genes Silencing and Fas Mrna Levels in Breast Tumors

Breast cancer development is associated with changes in expression of genes that involved in regulation of immune responses. Mucin 1 (MUC1) is aberrantly overexpressed in breast tumors. In cancer cells MUC1 gene expression changes, deviations from the normal protein glycosylation and intracellular localization changes is recorded. MUC1 properties changes lead to metabolic reprogramming, new functions appearance and play an important role in the development of tumors. NF-Kβ linking stimulates the release of inflammatory mediators, cytokines such as IL6.

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