Opera Medica et Physiologica

A.A. Mironov

The Role of the Medial Preoptic Area Glycinergic System in the Social Types of Behavior Regulation

Medial preoptic area (mPOA) is critically involved in the regulation of male sexual behavior in all vertebrate species in which its role has been studied. Electric stimulation of this area determines consummatory phase of sexual behavior, while mPOA lesions in model experiments inhibit this type of behavior. Furthermore, the studies performed with mPOA slices of male rats showed that fast inhibitory responses in mPOA neurons depend on GABA and glycine. Also mPOA is involved in social recognition regulation.

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Abstract

The medial preoptic nucleus is critically involved in the social type of behavior regulation, such as parental behaviour, social recognition, sexual behaviour, ect.. A big amount of studies are focused on the role of glutamate, GABA, serotonin, and dopamine systems of medial preoptic area (mPOA) in the social types of behaviour regulation. However, the role of glycinergic system in this nucleus has not been investigated.

On the Work of Spf Animal Facility

The animal facility is a complex system of special quarters and equipment for keeping and breeding of laboratory animals. The SPF (specific pathogen free) status of an animal facility means that the laboratory animals are free of particular pathogens causing various infectious diseases in mice and rats. Working with SPF animals under such conditions allows us to answer the question posed in the study.

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